招生专业

海洋化学

个人详细介绍

1998年,获188bet下载高分子研究所博士研究生学位;现任188bet下载海洋学院教授,博士研究生导师,海洋微生物功能分子广东省高校重点实验室副主任。2003-2004年美国弗吉尼亚大学访问学者。研究方向主要为海洋天然产物的发现及应用。先后主持和承担了863计划项目,国家自然科学基金,国家海洋公益性行业专项等10余项课题。在Tetrahedron、Organic Letter、J.Chromatogr、Planta Medica.、Mar.Drugs等杂志发表论文60余篇,获授权专利发明10余项。

代表性科研项目

1. 国家自然科学基金:南海红树林真菌抗肿瘤活性代谢产物研究

2. 国家自然科学基金:用分子烙印技术分离手性药物对映体的研究

3. 国家公益性行业(海洋)专项:海洋微生物小分子化合物资源库构建及药源活性物质的筛选应用(子课题)

4. 高校科研基本业务费项目:南海红树林真菌BL321活性次生代谢产物的分离和结构改造

5. 广东省自然科学基金:纤维素类手性固定相分离药物对映体的研究

代表性学术成果

1.New Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#.Natural product research, 2017, 31(3): 326-332.

2.Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#.Natural product research, 2016, 30(7): 755-760.

3.A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93.Natural product research,2016, 30(20): 2305-2310.

4.Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#.Marine Drugs, 2015,13(10): 6306-6318.

5.A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus

Penicillium sp. Natural product research,2015,10(9): 1549-1551.

6. Meroterpenes and azaphilones from marinemangrove endophytic fungus Penicillium 303# Fitoterapia,97(9),241-246,2014.

7. Alterporriol-type dimers from the mangroveendophytic fungus,Alternaria sp.(SK11),and their MptpB

inhibitions. Marine Drugs,12(5),2953-2969,2014

8.Loddigesiinols G-J: alpha-glucosidaseinhibitors from Dendrobium loddigesii. Molecules,19(6),8544-8555,2014.

9.Studies on the Synthesis of Derivatives ofMarine-Derived Bostrycin and Their Structure-Activity Relationship

against Tumor Cells, Marine Drugs,10(4),932-952,2012.

10.Four eremophilane sesquiterpenes from themangrove endophytic fungus Xylaria sp.Bl321.Marine Drugs,10:340-348,2011.

11.Metabolites of Mangrove Fungus Xylaria sp.(BL321) from the South China Sea,Planta Medica.2012,78(2):172-176.

12.Synthesis and cytotoxicevaluation of eremophilane sesquiterpene S6-2 derivatives.Chem.Pharm.Bull,59(9): 1186-1189 ,2011.

13.Structural elucidation and NMR assignments offour aromatic lactones from a mangrove endophytic fungus (No.GX4-1B).MagneticResonance in Chemistry,48(6):496-499,2010.

14.3,3'-Functionalized octahydro BINOL:  a facilesynthesis  and  its  high  enantioselectivity  in  the  alkyne

addition  to aldehydes.Tetrahedron,2004,60(34):7427-7430.